Lapidus Lab


Nagarajan, S. and L.J. Lapidus, Fluorescent probe DCVJ shows high sensitivity for characterization of amyloid beta peptide early in the lag phase. ChemBioChem: (in press)

Lapidus LJ. Protein unfolding mechanisms and their effects on folding experiments [version 1; referees: 2 approved]. F1000Research 6(F1000 Faculty Rev):1723 (2017).

Collier, T.J., K.R. Srivastava, C. Justman, T. Grammatopoulous, B. Hutter-Paier, M. Prokesch, D. Havas, J.-C. Rochet, F. Liu, K. Jock, P. de Oliveira, G.L. Stirtz, U. Dettmer, C.E. Sortwell, M.B. Feany, P. Lansbury, L. Lapidus, and K.L. Paumier, Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiology of Disease, 106: p. 191-204 (2017).

Srivastava, K.R. and L.J. Lapidus, Prion protein dynamics before aggregation. Proceedings of the National Academy of Sciences, 114(14): p. 3572-3577 (2017).

Izadi, D., T. Nguyen, and L. Lapidus, Complete Procedure for Fabrication of a Fused Silica Ultrarapid Microfluidic Mixer Used in Biophysical Measurements. Micromachines, 8(1): p. 16 (2017).

Dutta, G., S. Nagarajan, L.J. Lapidus, and P.B. Lillehoj, Enzyme-free electrochemical immunosensor based on methylene blue and the electro-oxidation of hydrazine on Pt nanoparticles. Biosensors and Bioelectronics, 92: p. 372-377 (2017).

S. Acharya, K.R. Srivastava, S. Nagarajan, L.J. Lapidus, Monomer dynamics of the Alzheimer peptides and Kinetic Control of Early Aggregation in Alzheimer’s Disease ChemPhysChem 17(21): p. 3470-3479 (2016)

K.R. Srivastava, K.C. French, F.O. Tzul, G.I. Makhatadze, L.J. Lapidus Intramolecular diffusion controls aggregation of the PAPf39 peptide Biophysical Chemistry 216 p.37-43 (2016)

S. Acharya, S. Saha, B. Ahmad, L.J. Lapidus, Effects of Mutations on the Reconfiguration Rate of α-Synuclein Journal of Physical Chemistry B 119 p.15443-15450 (2015)

L.J. Lapidus, S. Acharya, C. Schwantes, L. Wu, D. Shukla, M. King, S.J. DeCamp, V.S. Pande, Complex Pathways in Folding of Protein G Explored by Simulation and Experiment, Biophysical Journal 107 p. 947-955 (2014)

S. Acharya, B.M. Safaie, P. Wongkongkathep, M.I. Ivanova, A. Attar, F.G. Klärner, T. Schrader, J.A. Loo, G. Bitan, L.J. Lapidus, Molecular Basis for Preventing a-synuclein Aggregation by a Molecular Tweezer, Journal of Biological Chemisty 289 p. 10727-10737 (2014)

L. Zhu, N. Kurt, L. Choi, L.J. Lapidus, S. Cavagnero, Sub-millisecond Chain Collapse of the Escherichia coli Globin ApoHmpH. Journal of Physical Chemistry B, 117 (26) p. 7868-7877 (2013).

L. Wu, L.J. Lapidus, Combining Ultrarapid Mixing with Photochemical Oxidation to Probe Protein Folding. Journal of Analytical Chemistry. 85 (10) p. 4920-4924 (2013).

L. J. Lapidus, Exploring the Top of Protein Folding Funnel by Experiment, Current Opinion in Structural Biology. 23 p. 30-35 (2013).

L.J. Lapidus, Understanding Protein Aggregation from the View of Monomer Dynamics, Molecular Biosystems. 9 p. 29-35 (2012).

R. Narayanan, L. Zhu, Y. Velmurugu, J. Roca, S.V. Kuznetsov, G. Prehna, L.J. Lapidus, A. Ansari, Exploring the Energy Landscape of Nucleic Acid Hairpins using Laser Temperature-Jump and Microfluidic Mixing, Journal of the American Chemical Society. 134 (46) p. 18952-18963 (2012).

V.A. Voelz, M. Jäger, S. Yao, Y. Chen, L. Zhu, S.A. Waldauer, G.R. Bowman, M. Friedrichs, O. Bakajin, L.J. Lapidus, S. Weiss, V.S. Pande,Slow Unfolded-State Structuring in Acyl-CoA Binding Protein Folding Revealed by Simulation and Experiment, Journal of the American Chemical Society 134 (30) p. 12565–12577 (2012).

B. Ahmad, L.J. Lapidus, Curcumin Prevents alpha-synuclein Aggregation by Controlling Intramolecular Diffusion Journal of Biological Chemistry 287(12): p. 9193-9199 (2012).

B. Ahmad, Y. Chen, L.J. Lapidus, Aggregation of alpha-synuclein is Kinetically Controlled by Intramolecular Diffusion, Proceedings of the National Academy of Sciences. 109(7): p. 2336-2341(2012).

S. A. Waldauer, L. Wu, S. Yao, O. Bakajin, L.J. Lapidus, Microfluidic Mixers for Studying Protein Folding, Journal of Visualized Experiments 62: p. e3976.(2012)

L. Zhu, K. Ghosh, M. King, T. Cellmer, O. Bakajin, L.J. Lapidus, Evidence of Multiple Folding Pathways for the Villin Headpiece Subdomain. J. Phys Chem B. 115, 12632-12637 (2011).

Y. Chen, W.J. Wedemeyer, L.J. Lapidus, A General Model of Unfolded Proteins under Folding Conditions. J. Phys. Chem. B. 114, 15969-15975 (2010).

S. A. Waladauer, O. Bakajin, L.J. Lapidus, Extremely Slow Intramolecular Diffusion in Unfolded Protein L, Proceedings of the National Academy of Sciences 107, 13713-13717 (2010).

V.A. Voelz, V.R. Singh, W.J. Wedemeyer, L.J. Lapidus, V.S. Pande, Unfolded state dynamics and structure of protein L characterized by simulation and experiment.Journal of the American Chemical Society, 132 4702-4709 (2010).

Y. Chen, C. Parrini, N. Taddei, L.J. Lapidus, Conformational Properties of Unfolded HypF-N, J. Phys. Chem. B 113, 16209-16213 (2009).

S. DeCamp, Waldauer, A. Naganathan, O. Bakajin, L.J. Lapidus, Direct Observation of Downhill folding of lambda-repressor in a Microfluidic Mixer, Biophysical. Journal, 97, 1772-1777 (2009).

R. Saravana, E. Slabuagh, V.R. Singh, L.J. Lapidus, T. Haas, F. Brandizzi, The targeting of the oxysterol-binding protein ORP3a to the endoplamic reticulum relies on the plant VAP33 homolog PVA12, The Plant Journal, 58, 817-830 (2009).

S. Waldauer, O. Bakajin, T. Ball, Y. Chen, S. DeCamp, M. Kopka, M. Jäger, V.R. Singh, W.J. Wedemeyer, S. Weiss, S. Yao, L.J. Lapidus, Ruggedness in the Folding Landscape of Protein L,HFSP Journal, 2, 388-395 (2008).

V.R. Singh, L.J. Lapidus, The Intrinsic Stiffness of Polyglutamine Peptides. Journal of Physical Chemistry B, 112, 13172-13176 (2008)

V.R. Singh, M. Kopka, Y. Chen, W.S. Wedemeyer, L.J. Lapidus, Dynamic Similarity of the Unfolded States of Proteins L and G. Biochemistry, 46, 10046-10054 (2007).

L.J. Lapidus, S. Yao, K. McGarrity, D. Hertzog, E. Tubman, O. Bakajin, Protein Hydrophobic Collapse and Early Folding Steps Observed in a Microfluidic Mixer Biophysical Journal, 93, 218-224 (2007).

T. H. Lee, L. J. Lapidus, W. Zhao, K. J. Travers, D. Herschlag, and S. Chu, Measuring the Folding Transition Time of Single RNA Molecules. Biophysical Journal, 92, 3275-3283 (2007).

M. Buscaglia, L.J. Lapidus, W.A. Eaton, and J. Hofrichter,Effects of Denaturants on the Dynamics of Loop Formation in Polypeptides.Biophysical Journal,91, p. 276-288 (2006).

M. Buscaglia, B. Schuler, L. J. Lapidus, W.A. Eaton, J. Hofrichter, Kinetics of intramolecular contact formation in a denatured protein.Journal of Molelcular Biology, 332, 9-12(2003)

L.J. Lapidus, P.J. Steinbach, W.A. Eaton, A. Szabo and J. Hofrichter, Effects of chain stiffness on the dynamics of loop formation in polypeptides. Appendix: Testing a 1-dimensional diffusion model for peptide dynamics.Journal of Physical Chemistry B, 106,11628 (2002).

L.J. Lapidus, W.A. Eaton and J. Hofrichter, Measuring dynamic flexibility of the coil state of a helix-forming peptide. Journal of Molelcular Biology, 319, 19 (2002).

L.J. Lapidus, W.A. Eaton and J. Hofrichter, Dynamics of intramolecular contact formation in polypeptides: distance dependence of quenching rates in a room-temperature glass. Physical Review Letters, 87, 8101 (2001).

L.J. Lapidus, W.A. Eaton and J. Hofrichter, Measuring the rate of intramolecular contact formation in polypeptides Proceedings of the National Academy of Sciences USA 97, 7220 (2000).

W.A. Eaton, V. Muñoz, S.J. Hagen, G.S. Jas, L.J. Lapidus, E.R. Henry, J. Hofrichter, Fast Kinetics and Mechanisms in Protein Folding. Ann. Rev. Biophys. Biomol. Struct. 29, 327-359 (2000).

. Hofrichter, P.A. Thompson, V. Muñoz, G.S. Jas, E. Henry, S. Hagen, L.J. Lapidus, W.A. Eaton, Dynamics of a-Helices, b-Hairpins and Loops. In Old and New Views of Protein Folding edited by K. Kuwajuma and M. Arai, Elsevier Science B.V., pp. 53-62 (1999).

L.J. Lapidus, D. Enzer and G. Gabrielse, Stochastic Phase-Switching of a Single Parametrically Excited Electron in a Penning Trap. Physical Review Letters, 83, 889 (1998).

R.S. Conti, S. Hatamian, L. Lapidus, A. Rich, M. Skalsey, Search for C-violating, P-conserving Interactions and Observation of 23S1 to 21P1 Transitions in Positronium.Phys. Lett. A. 177, 43-48 (1993).