SCIENCE AT THE EDGE SEMINAR Friday, November 03,2006 at 11:30am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 11:15 Speaker: Alessandro Vespignani Biocomplexity Institute, Indiana University Title: Epidemic spreading in complex networks Abstract: Networks which trace the activities and interactions of individuals, social patterns, transportation fluxes and population movements on a local and global scale have been analyzed and found to exhibit complex features encoded in large scale heterogeneity, self-organization and other properties typical of complex systems. We review the impact of these complex features on the behavior of epidemic spreading processes. We first discuss the general framework obtained for basic compartmental models (SIR, SIS) and review the results concerning the epidemic threshold and dynamical evolution of disease spreading processes in complex population networks. We then report on the effect of the heterogeneity of real world transportation networks in realistic meta-population models for the forecast of the large scale spreading of emerging diseases. The specific cases of SARS, and pandemic influenza are analyzed.