SCIENCE AT THE EDGE SEMINAR

Friday, 09 September 2011 at 11:30am

Room 1400 Biomedical and Physical Sciences Bldg.

Refreshments at 11:15

Speaker: Haixu Tang
         Department of Informatics and Computing, Indiana University

Title:   Next Generation Software Tools for Next Generation Sequence Analysis


Abstract:

The rapid advance of the massively parallel sequencing (often referred to as the
Next Generation Sequencing, NGS) technologies has revolutionized DNA sequencing
by reducing both its throughtput and cost by several magnitudes in the past few
years.  As a result, DNA sequencing has become available for not only large
genome centers, but also individual biological labs, a trend called the
democratized genomics. With the fast-growing applications of NGS on a wide
spectrum of biological problems, ranging from gene expression analysis (i.e.,
RNA-seq) to metagenomics, pressures are mounting on the bioinformatics community
to come up with software systems to analyze such data. In this talk, I will
present a few case studies to address the computational challenges to design and
implement these sequence analysis systems, with focuses on the requirements of
Simplicity, Scalability, Speed and Security of the systems.