SCIENCE AT THE EDGE SEMINAR SERIES Quantum Biology / Gene Expression in Development and Disease Seminar Friday, 23 September 2011 at 11:30am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 11:15 Speaker: Shizhong Xu Department of Botany & Plant Sciences, Univ. of California, Riverside Title: Using Genome-wide Marker Information to Detect Natural Selection Abstract: Viability selection will cause fitness related genes to deviate from the expected Mendelian segregation. These loci are called viability selection loci. Molecular markers closedly inked with these viability loci will show distorted segregation. Using the distorted markers, we can locate the viability loci. In this study, we develop a generalized linear model to map the viability selection loci using genome-wide high density marker information. Parameters of the generalized linear model are estimated using the maximum-a-posteriori (MAP) approach. A real life example is used to demonstrate the generalized linear model.