SCIENCE AT THE EDGE SEMINAR SERIES
Interdisciplinary Physics Seminar
Friday, 28 October 2011 at 11:30am
Room 1400 Biomedical and Physical Sciences Bldg.
Refreshments at 11:15
Speaker: Gianluca Ascolani
Laboratory IMNC, CNRS-UMR8165, Orsay, France
Title: Glioma Cells Exchanging Information Via Gap Junctions
and Their Migration Process
Abstract:
One of the main aspects of studying diffuse tumors is understanding how
they diffuse and how fast they spread. To shed light on these issues, we
use an approach based on a microscopical description of the cells' dynamics
to reproduce the evolution at the meso-macroscopical scale.
An example of a tumor is the glioblastoma which grows in the brain and is
very invasive. The glioma cells of the glioblastoma interact with other
cancerous cells exchanging small molecules and ions through very short links
named gap junction connections.
We propose a model in the framework of automaton for the migration of
cancerous cells that takes into consideration gap junctional exchange of
information. The cells move on a single occupancy sites lattice and interact
with the nearest neighbors. The interaction affects the motion of cells by
imposing the condition of preserving at least one gap junction
connection among the closest neighbors with a given probability.
We show the hydrodynamic limit of the cells' diffusion equation in the
mean field-approximation and the effects of gap junctions on the migration
process of cancerous cells in terms of the two-points correlation function.