Lab Research Interest
The Comstock lab investigates fundamental physical processes in biology using advanced, precision single-molecule measurement and manipulation techniques. We observe in real-time individual protein molecular machines marching down DNA strands or ripping open RNA. We manipulate live cells and measure individual cellular electrochemistry. To do this we design and build frontier biophysical instrumentation combining optical tweezers and single-molecule fluorescence microscopy. We strive to watch biology in action without the obscuring effects of traditional ensemble methods.
We are a young interdisciplinary lab composed of scientists with a diversity of backgrounds. Students have the opportunity to participate in all aspects of biophysical research including: wet lab development and production of biological systems, design and construction of instrumentation (optics, electronics, software etc.), quantitative data analysis and modeling and collegial discussion. We are always on the lookout for excited new colleagues. Interested students and postdocs with a background in physics, biology, chemistry, or a related field are welcome to contact Prof. Comstock.